diff --git a/loopd/swapclient_server.go b/loopd/swapclient_server.go
index 1e3f925..550504a 100644
--- a/loopd/swapclient_server.go
+++ b/loopd/swapclient_server.go
@@ -8,6 +8,7 @@ import (
 	"sync"
 	"time"
 
+	"github.com/btcsuite/btcd/chaincfg"
 	"github.com/btcsuite/btcutil"
 	"github.com/lightninglabs/lndclient"
 	"github.com/lightninglabs/loop"
@@ -35,6 +36,11 @@ const (
 )
 
 var (
+	// errIncorrectChain is returned when the format of the
+	// destination address provided does not match the active chain.
+	errIncorrectChain = errors.New("invalid address format for the " +
+		"active chain")
+
 	// errConfTargetTooLow is returned when the chosen confirmation target
 	// is below the allowed minimum.
 	errConfTargetTooLow = errors.New("confirmation target too low")
@@ -82,8 +88,9 @@ func (s *swapClientServer) LoopOut(ctx context.Context,
 		}
 	}
 
-	sweepConfTarget, err := validateLoopOutRequest(in.SweepConfTarget,
-		in.Label)
+	sweepConfTarget, err := validateLoopOutRequest(
+		s.lnd.ChainParams, in.SweepConfTarget, sweepAddr, in.Label,
+	)
 	if err != nil {
 		return nil, err
 	}
@@ -922,9 +929,17 @@ func validateLoopInRequest(htlcConfTarget int32, external bool) (int32, error) {
 	return validateConfTarget(htlcConfTarget, loop.DefaultHtlcConfTarget)
 }
 
-// validateLoopOutRequest validates the confirmation target and label of the
-// loop out request.
-func validateLoopOutRequest(confTarget int32, label string) (int32, error) {
+// validateLoopOutRequest validates the confirmation target, destination
+// address and label of the loop out request.
+func validateLoopOutRequest(chainParams *chaincfg.Params, confTarget int32,
+	sweepAddr btcutil.Address, label string) (int32, error) {
+	// Check that the provided destination address has the correct format
+	// for the active network.
+	if !sweepAddr.IsForNet(chainParams) {
+		return 0, fmt.Errorf("%w: Current active network is %s",
+			errIncorrectChain, chainParams.Name)
+	}
+
 	// Check that the label is valid.
 	if err := labels.Validate(label); err != nil {
 		return 0, err
diff --git a/loopd/swapclient_server_test.go b/loopd/swapclient_server_test.go
index 418eb36..47bf141 100644
--- a/loopd/swapclient_server_test.go
+++ b/loopd/swapclient_server_test.go
@@ -163,13 +163,53 @@ func TestValidateLoopInRequest(t *testing.T) {
 func TestValidateLoopOutRequest(t *testing.T) {
 	tests := []struct {
 		name           string
+		chain          chaincfg.Params
 		confTarget     int32
+		destAddr       btcutil.Address
 		label          string
 		err            error
 		expectedTarget int32
 	}{
+		{
+			name:           "mainnet address with mainnet backend",
+			chain:          chaincfg.MainNetParams,
+			destAddr:       mainnetAddr,
+			label:          "label ok",
+			confTarget:     2,
+			err:            nil,
+			expectedTarget: 2,
+		},
+		{
+			name:           "mainnet address with testnet backend",
+			chain:          chaincfg.TestNet3Params,
+			destAddr:       mainnetAddr,
+			label:          "label ok",
+			confTarget:     2,
+			err:            errIncorrectChain,
+			expectedTarget: 0,
+		},
+		{
+			name:           "testnet address with testnet backend",
+			chain:          chaincfg.TestNet3Params,
+			destAddr:       testnetAddr,
+			label:          "label ok",
+			confTarget:     2,
+			err:            nil,
+			expectedTarget: 2,
+		},
+		{
+			name:           "testnet address with mainnet backend",
+			chain:          chaincfg.MainNetParams,
+			destAddr:       testnetAddr,
+			label:          "label ok",
+			confTarget:     2,
+			err:            errIncorrectChain,
+			expectedTarget: 0,
+		},
 		{
 			name:           "invalid label",
+			chain:          chaincfg.MainNetParams,
+			destAddr:       mainnetAddr,
 			label:          labels.Reserved,
 			confTarget:     2,
 			err:            labels.ErrReservedPrefix,
@@ -177,6 +217,8 @@ func TestValidateLoopOutRequest(t *testing.T) {
 		},
 		{
 			name:           "invalid conf target",
+			chain:          chaincfg.MainNetParams,
+			destAddr:       mainnetAddr,
 			label:          "label ok",
 			confTarget:     1,
 			err:            errConfTargetTooLow,
@@ -184,6 +226,8 @@ func TestValidateLoopOutRequest(t *testing.T) {
 		},
 		{
 			name:           "default conf target",
+			chain:          chaincfg.MainNetParams,
+			destAddr:       mainnetAddr,
 			label:          "label ok",
 			confTarget:     0,
 			err:            nil,
@@ -198,7 +242,8 @@ func TestValidateLoopOutRequest(t *testing.T) {
 			t.Parallel()
 
 			conf, err := validateLoopOutRequest(
-				test.confTarget, test.label,
+				&test.chain, test.confTarget, test.destAddr,
+				test.label,
 			)
 			require.True(t, errors.Is(err, test.err))
 			require.Equal(t, test.expectedTarget, conf)