There are many different options to install python environment on macOS ([official](https://www.python.org/downloads/mac-osx/), [anaconda](https://conda.io/docs/user-guide/install/macos.html), ..). Most importantly you need `libusb`. Probably the easiest way is via [homebrew](https://brew.sh/)
$ brew install libusb
### GPG
If you intend to use GPG make sure you have GPG installed and up to date. This software requires a GPG version >= 2.1.11.